After an engineering degree at INSA Toulouse, I started my PhD under the supervision of Florence TATIN. Our main work focuses on the lymphatic network in the skin and its association with adipose tissue.
Visualizing the architecture of the lymphatic network in adult organs is really challenging due to limit on antibody labelling and confocal microscopy. We used light-sheet microscopy to characterize and quantify the 3D-architecture of the lymphatic network in the skin, and its disruption in secondary lymphedema.
Alterations of the vascular architecture are involved in a broad spectrum of human disorders. SVEP1 is a secreted protein critical for lymphatic development. Using bioinformatics analysis of single cell RNA sequencing, we found that SVEP1 expression is restricted to adipocyte progenitors in adipose tissue and is overexpressed in obesogenic conditions. Our work reveals that SVEP1 contributes to vascular morphogenesis in the pathologies of lymphedema and obesity
Endothelial Cell Phenotypes in Health and Disease – June 26 – July 1, 2022 – Travel Award