Programme Définitif
Les
présentations se feront en français ou en anglais, les
diapositives et les posters seront en anglais.
Les posters seront affichés sur panneaux en dur (pas de punaises), des gommettes ou de l'adhésif double face sera fourni.
Dimanche 9 Mai 2010
16:00 – 18:00
Accueil et
Inscriptions
18:00 – 18:15 Mot de bienvenue
Session 1 – Développement vasculaire et identité endothéliale
Modérateurs: Philippe HUBER, Luc PARDANAUD
18:15 – 18:55 Anne EICHMANN (Paris, France)
Basic mechanisms of vascular development
18:55 – 19:20 Cécile DUPLAA (Bordeaux, France)
Importance of frizzled 4 and 7 receptors in vascular morphogenesis
19:20 – 19:35 Emmanuelle TILLET (Grenoble, France)
Unraveling the distinct distributions of VE- and N-cadherins in endothelial
cells : a key role for p120 catenin
19:35 – 19:50 Sébastien GAUVRIT (Paris, France)
Role of RNA interference in epigenetic control of embryonic venouslymphatic
separation and hematopoiesis
19:50 – 20:05 Christine MOUSSION (Toulouse, France)
Dendritic Cells control HEV endothelial cell differentiation and Lymphocyte
entry into Lymph Node
20:30 Dîner – Hôtel Mercure
18:00 – 18:15 Mot de bienvenue
Session 1 – Développement vasculaire et identité endothéliale
Modérateurs: Philippe HUBER, Luc PARDANAUD
18:15 – 18:55 Anne EICHMANN (Paris, France)
Basic mechanisms of vascular development
18:55 – 19:20 Cécile DUPLAA (Bordeaux, France)
Importance of frizzled 4 and 7 receptors in vascular morphogenesis
19:20 – 19:35 Emmanuelle TILLET (Grenoble, France)
Unraveling the distinct distributions of VE- and N-cadherins in endothelial
cells : a key role for p120 catenin
19:35 – 19:50 Sébastien GAUVRIT (Paris, France)
Role of RNA interference in epigenetic control of embryonic venouslymphatic
separation and hematopoiesis
19:50 – 20:05 Christine MOUSSION (Toulouse, France)
Dendritic Cells control HEV endothelial cell differentiation and Lymphocyte
entry into Lymph Node
20:30 Dîner – Hôtel Mercure
Lundi 10 Mai 2010
Session
2 – Hypoxie et facteurs angiogéniques
Modérateurs: Martine APPLANAT, Fabrice SONCIN
08:30 – 09:10 Peter RATCLIFFE (Oxford, Grande-Bretagne)
Signalling hypoxia in cells; the HIF hydroxylase system
09:10 – 09:35 Olivier CUVILLIER (Toulouse, France)
Targeting intratumoral hypoxia by a sphingosine 1-phosphate antibody
sensitizes to chemotherapy in prostate cancer
09:35 – 09:50 Fatima MECHTA-GRIGOURIOU (Paris, France)
Oxidative stress promotes myofibroblast differentiation and tumor spreading
09:50 – 10:05 Barbara GARMY-SUSINI (Toulouse, France)
Hypoxia induces translational regulation of lymphangiogenic growth factors
10:05 – 10:20 Nadejda VINTONENKO (Paris, France)
Anchorage of VEGF conveys similar and/or differential responses to tumor
cells ?
10:20 – 11:30 Pause café, visite des posters et des stands
Session 3 – Progéniteurs et vasculogenèse post-natale
Modérateurs: Jean-Jacques FEIGE, Jean-Sébastien SILVESTRE
11:30 – 12:10 Georges UZAN (Villejuif, France)
Progéniteurs endothéliaux et vasculogenèse post-natale
12:10 – 12:25 Claire BOUVARD (Paris, France)
Alpha6 integrin subunit plays a major role in the proangiogenic properties
of endothelial progenitor cells
12:25 – 12:40 Clément COCHAIN (Paris, France)
MerTK and MFGE8 dependent phagocytic pathways control the
proangiogenic activity of bone marrow derived cells
12:40 – 13:05 Daniel VITTET (Grenoble, France)
Blockade of TGFß enhances endothelial lymphatic development during
mouse embryonic stem cell in vitro differentiation
13:15 Déjeuner – Hôtel Mercure
Session 4 – Micro-environnement et angiogenèse pathologique
Modérateurs: Danièle MATHIEU, Stéphane GERMAIN
14:30 – 15:10 Michele DE PALMA (Milan, Italie)
Macrophage Heterogeneity in the Tumor Microenvironment: Implications
for Angiogenesis and Antiangiogenic Therapy
15:10 – 15:25 Caroline GEST (Rouen, France)
Cooperation between MDA-MB-231 and macrophages: angiogenesis
modulation by tetrathiomolybdate
15:25 – 15:40 Armelle LE GUELTE (Paris, France)
Effect of tumor microenvironment on the properties on brain endothelial
cells
15:40 – 15:55 Ariane GALAUP (Paris, France)
Characterization of the molecular mechanisms by which ANGPTL4 affects
the tumor process
15:55 – 16:10 Mélanie MORIN (Montpellier, France)
VEGFR-2 signalling: New targets to repair blood-brain barrier in epilepsy?
16:10 – 16:35 Valérie PINET (Montpellier, France)
LYL activity is required for the maturation of newly formed blood vessels in
adulthood
16:35 – 17:45 Pause café, visite des posters et des stands
Session 5 – Bilan clinique des traitements anti-angiogéniques
Modérateurs: Anne EICHMANN, Marc POCARD
17:45 – 18:25 Pierre FUMOLEAU (Dijon, France)
Antiangiogenic therapy in breast cancer
18:25 – 18:40 Nunzia TACELLI (Lille, France)
Quantitative tumor perfusion assessment with 64-slice multidetector-row CT
(MDCT): evaluation before and after antiangiogenic chemotherapy
18:40 – 18:55 Clarisse EVENO (Paris, France)
Angiogenesis going with hepatic metastatic process and hepatic
regeneration is reflected in modification of blood flow velocities in hepatic
artery in an orthotopic human colon cancer and a hepatectomy murine
model
18:55 – 19:10 Samly SRUN (Paris, France)
Thalidomide stimulates vessel maturation and reduces epistaxis in
Hereditary Hemorrhagic Telangiectasia patients
19:10 – 19:35 François PARIS (Nantes, France)
Membrane-related mechanisms involved in endothelial cell apoptosis and
potentially in tissue and tumor response after radiotherapy
19:35 Assemblée Générale de la SFA
20:30 Dîner de Gala – Hôtel Mercure
Modérateurs: Martine APPLANAT, Fabrice SONCIN
08:30 – 09:10 Peter RATCLIFFE (Oxford, Grande-Bretagne)
Signalling hypoxia in cells; the HIF hydroxylase system
09:10 – 09:35 Olivier CUVILLIER (Toulouse, France)
Targeting intratumoral hypoxia by a sphingosine 1-phosphate antibody
sensitizes to chemotherapy in prostate cancer
09:35 – 09:50 Fatima MECHTA-GRIGOURIOU (Paris, France)
Oxidative stress promotes myofibroblast differentiation and tumor spreading
09:50 – 10:05 Barbara GARMY-SUSINI (Toulouse, France)
Hypoxia induces translational regulation of lymphangiogenic growth factors
10:05 – 10:20 Nadejda VINTONENKO (Paris, France)
Anchorage of VEGF conveys similar and/or differential responses to tumor
cells ?
10:20 – 11:30 Pause café, visite des posters et des stands
Session 3 – Progéniteurs et vasculogenèse post-natale
Modérateurs: Jean-Jacques FEIGE, Jean-Sébastien SILVESTRE
11:30 – 12:10 Georges UZAN (Villejuif, France)
Progéniteurs endothéliaux et vasculogenèse post-natale
12:10 – 12:25 Claire BOUVARD (Paris, France)
Alpha6 integrin subunit plays a major role in the proangiogenic properties
of endothelial progenitor cells
12:25 – 12:40 Clément COCHAIN (Paris, France)
MerTK and MFGE8 dependent phagocytic pathways control the
proangiogenic activity of bone marrow derived cells
12:40 – 13:05 Daniel VITTET (Grenoble, France)
Blockade of TGFß enhances endothelial lymphatic development during
mouse embryonic stem cell in vitro differentiation
13:15 Déjeuner – Hôtel Mercure
Session 4 – Micro-environnement et angiogenèse pathologique
Modérateurs: Danièle MATHIEU, Stéphane GERMAIN
14:30 – 15:10 Michele DE PALMA (Milan, Italie)
Macrophage Heterogeneity in the Tumor Microenvironment: Implications
for Angiogenesis and Antiangiogenic Therapy
15:10 – 15:25 Caroline GEST (Rouen, France)
Cooperation between MDA-MB-231 and macrophages: angiogenesis
modulation by tetrathiomolybdate
15:25 – 15:40 Armelle LE GUELTE (Paris, France)
Effect of tumor microenvironment on the properties on brain endothelial
cells
15:40 – 15:55 Ariane GALAUP (Paris, France)
Characterization of the molecular mechanisms by which ANGPTL4 affects
the tumor process
15:55 – 16:10 Mélanie MORIN (Montpellier, France)
VEGFR-2 signalling: New targets to repair blood-brain barrier in epilepsy?
16:10 – 16:35 Valérie PINET (Montpellier, France)
LYL activity is required for the maturation of newly formed blood vessels in
adulthood
16:35 – 17:45 Pause café, visite des posters et des stands
Session 5 – Bilan clinique des traitements anti-angiogéniques
Modérateurs: Anne EICHMANN, Marc POCARD
17:45 – 18:25 Pierre FUMOLEAU (Dijon, France)
Antiangiogenic therapy in breast cancer
18:25 – 18:40 Nunzia TACELLI (Lille, France)
Quantitative tumor perfusion assessment with 64-slice multidetector-row CT
(MDCT): evaluation before and after antiangiogenic chemotherapy
18:40 – 18:55 Clarisse EVENO (Paris, France)
Angiogenesis going with hepatic metastatic process and hepatic
regeneration is reflected in modification of blood flow velocities in hepatic
artery in an orthotopic human colon cancer and a hepatectomy murine
model
18:55 – 19:10 Samly SRUN (Paris, France)
Thalidomide stimulates vessel maturation and reduces epistaxis in
Hereditary Hemorrhagic Telangiectasia patients
19:10 – 19:35 François PARIS (Nantes, France)
Membrane-related mechanisms involved in endothelial cell apoptosis and
potentially in tissue and tumor response after radiotherapy
19:35 Assemblée Générale de la SFA
20:30 Dîner de Gala – Hôtel Mercure
Mardi 11 Mai 2010
Session
6 – Néovascularisation et invasion tumorale
Modérateurs: Agnès NOEL, Andréas BIKFALVI
08:30 – 09:10 Agnès NOËL (Liège, Belgique)
The metalloproteinase landscape in the tumor environment: impact on
(lymph) angiogenesis and metastatic dissemination
09:10 – 09:35 Amel METTOUCHI (Nice, France)
Role of alpha2beta1 integrins in the control of angiogenesis
09:35 – 09:50 Mathieu BERGE (Paris, France)
Neuropilin-1 is upregulated in hepatocellular carcinoma and contributes to
tumor growth and vasculature remodelling
09:50 – 10:05 Arnaud JABOUILLE (Talence, France)
A shift from an angiogenic to invasive phenotype induced in malignant
glioma by inhibition of the Unfolded Protein Response sensor IRE1
10:05 – 10:20 Elodie PERES (Caen, France)
The endogenous EPO/EPOR system is a critical player in glioma growth
10:20 – 10:45 Pause café, visite des posters et des stands
Session 7 – Thérapies anti-angiogéniques : cibles, biomarqueurs et échappement
tumoral
Modérateurs: Yves AUDIGIER, Gilles PAGES
10:45 – 11:25 Lidia MOSERLE (Barcelone, Espagne)
Anti-angiogenic therapies : targets, effectiveness and tumoral adaptation
11:25 – 11:40 Renaud GREPIN (Nice, France)
Acceleration of clear cell renal cell carcinoma growth in mice following
Bevacizumab/ Avastin® treatment
11:40 – 11:55 Bernard MASRI (Toulouse, France)
Identification and pharmacological properties of a potent antagonist of
apelin receptors
11:55 – 12:10 Pierre FONS (Toulouse, France)
Evaluation of a monoclonal antibody targeting Tie-1 in co-culture assays
12:10 – 10:25 Romain DELCOMBEL (Liège, Belgique)
VEGF111 : Dr. Jekyll and Mr. Hyde ?
12:25 – 12:50 Béatrice EYMIN (Grenoble, France)
Le facteur de transcription E2F1 et le facteur d’épissage SC35 contrôlent la
balance des isoformes pro-(VEGFxxx) versus anti-(VEGFxxxb) angiogéniques
du VEGF-A pour inhiber la néoangiogénèse tumorale ”in vivo” dans des
modèles de carcinome broncho-pulmonaire
13:00 Déjeuner-buffet – Hôtel Mercure
Modérateurs: Agnès NOEL, Andréas BIKFALVI
08:30 – 09:10 Agnès NOËL (Liège, Belgique)
The metalloproteinase landscape in the tumor environment: impact on
(lymph) angiogenesis and metastatic dissemination
09:10 – 09:35 Amel METTOUCHI (Nice, France)
Role of alpha2beta1 integrins in the control of angiogenesis
09:35 – 09:50 Mathieu BERGE (Paris, France)
Neuropilin-1 is upregulated in hepatocellular carcinoma and contributes to
tumor growth and vasculature remodelling
09:50 – 10:05 Arnaud JABOUILLE (Talence, France)
A shift from an angiogenic to invasive phenotype induced in malignant
glioma by inhibition of the Unfolded Protein Response sensor IRE1
10:05 – 10:20 Elodie PERES (Caen, France)
The endogenous EPO/EPOR system is a critical player in glioma growth
10:20 – 10:45 Pause café, visite des posters et des stands
Session 7 – Thérapies anti-angiogéniques : cibles, biomarqueurs et échappement
tumoral
Modérateurs: Yves AUDIGIER, Gilles PAGES
10:45 – 11:25 Lidia MOSERLE (Barcelone, Espagne)
Anti-angiogenic therapies : targets, effectiveness and tumoral adaptation
11:25 – 11:40 Renaud GREPIN (Nice, France)
Acceleration of clear cell renal cell carcinoma growth in mice following
Bevacizumab/ Avastin® treatment
11:40 – 11:55 Bernard MASRI (Toulouse, France)
Identification and pharmacological properties of a potent antagonist of
apelin receptors
11:55 – 12:10 Pierre FONS (Toulouse, France)
Evaluation of a monoclonal antibody targeting Tie-1 in co-culture assays
12:10 – 10:25 Romain DELCOMBEL (Liège, Belgique)
VEGF111 : Dr. Jekyll and Mr. Hyde ?
12:25 – 12:50 Béatrice EYMIN (Grenoble, France)
Le facteur de transcription E2F1 et le facteur d’épissage SC35 contrôlent la
balance des isoformes pro-(VEGFxxx) versus anti-(VEGFxxxb) angiogéniques
du VEGF-A pour inhiber la néoangiogénèse tumorale ”in vivo” dans des
modèles de carcinome broncho-pulmonaire
13:00 Déjeuner-buffet – Hôtel Mercure
Fin
du congrès